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Pediatric Hematology Oncology - Project Scientist -Jonas Lab

University of California Los Angeles

Details

Posted: 18-Jul-24

Location: Los Angeles, California

Type: Full-time

Internal Number: 5262654

Pediatric Hematology Oncology - Project Scientist -Jonas Lab
University of California Los Angeles

Requisition Number: JPF09392

The Jonas Lab in the Department of Pediatrics, David Geffen School of Medicine & California NanoSystems Institute at UCLA is seeking a highly motivated project scientist interested in pursuing interdisciplinary research at the interface of nanoscience and regenerative medicine. We have a multidisciplinary research team interested in developing new nanotechnology-enabled methods to support the childhood cancer and regenerative medicine research communities in accelerating the discovery and implementation of gene and cellular therapeutic approaches and precision-medicine-based diagnostic strategies.

With support from the NIH's High-Risk High-Reward Program, our group leverages advances in microfluidics, nanofabrication, and gene editing approaches to explore the ultimate limits of miniaturization. These capabilities empower our efforts to create tools that enable stem cell biologists to probe and to interact with stem cells more precisely and empower clinical scientists to apply this knowledge to design and implement new therapies more rapidly and broadly.

We have multiple postdoctoral positions available immediately to:

Establish rapid, safe, cost-effective, and efficient intracellular delivery methods for genes and genome-editing machinery. The goal of this NIH-funded project is to establish new manufacturing platforms for gene and stem cell-based therapies directed at pediatric cancers, hematologic disorders, primary immunodeficiencies, and other genetic diseases.
Design and apply nanocarrier systems to enable cystic fibrosis gene therapies.
Develop microfluidic liquid biopsy technologies for monitoring treatment response to pediatric sarcomas and other childhood malignancies
Apply rapid prototyping approaches to fabricate three-dimensionally printed tools for organoid development & toxicity screening of electronic cigarette/vaping products

Qualifications:

PhD, MD/PhD, or equivalent in Bioengineering, Materials Science, Chemistry, Mechanical Engineering, Physics, Electrical Engineering, Molecular Biology or related life science fields of study

Background in nanoparticle synthesis & characterization and mRNA therapeutics

Solid understanding and experience in micro/nanofabrication techniques, microfluidic devices, three-dimensional printing, device design and characterization

Experience in cell culture, cell biology & molecular biology, immunofluorescence/flow cytometry, next generation sequencing techniques, gene editing methods, and biochemical techniques desired

Ability to multitask and quickly adapt to new research challenges

Excellent communication skills and ability to work in a diverse, interdisciplinary research environment and to interact with computational and experimental scientists

Ability to function independently in the laboratory and lead project teams

Desire to engage and mentor graduate, medical, and undergraduate students across different academic disciplines

Skills:

Experience with micro/nanofabrication techniques, including photolithography and three-dimensional printing for rapid prototyping and application of microfluidic systems

Experience in the design of computer models/simulations for prototyping of project-specific devices

Experience in nanoparticle synthesis and characterization (e.g., lipid nanoparticles, polymeric, plasmonic nanomaterials)

Experience with cell culture, transfection, immunofluorescence/flow cytometry, and biochemical and molecular biology techniques

Comfortable working with human primary cell types including hematopoietic stem cells, immune cells, or pluripotent stem cells.

Experience in the development and characterization of gene editing reagents, PCR, cloning, and/or Next-Generation sequencing desired

Working knowledge of laboratory notebook management and data management

Knowledge of aseptic and laboratory technique

Meticulous organizational and data analysis skills

Duties and Responsibilities:

Ability to work and lead more independently and multitask projects more extensively

Leadership and coordination of project activities and collaborative efforts. The candidate will report directly to the PI

Oversee development of technology platforms for cellular therapy manufacturing, nanoparticle vehicles, organoids, and/or liquid biopsy diagnostic tests and characterization of cell products resulting from this work

Ability to multitask and contribute to and oversee multiple collaborative projects efficiently and effectively

Supervision, mentorship, and teaching of undergraduate, graduate, and medical students, new postdoctoral trainees, and staff research associates in the lab

Required to communicate well with other scientists, regulatory personnel, biotech companies, sponsored research organizations, and other scientific personnel worldwide.

Supervise preparation of manuscripts for publication of results of independent and collaborative laboratory research. The candidate will also provide support in publishing the results of various projects.

Participate in laboratory meetings, educational sessions, general and specific safety training and other training sessions

Assist and work with PI directly to identify new opportunities and research directions for the laboratory

Assist PI in preparation of grant proposals and progress reports, as needed.

Desire to work toward transitioning to independence as an early-stage scientific investigator

Performs other duties and laboratory responsibilities as requested.

Interested candidates can apply online at https://recruit.apo.ucla.edu/JPF09392

Cultural North Star
The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what's right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

Anti-Racism Roadmap
The David Geffen School of Medicine Anti-racism roadmap is our co-created path to ensuring racial justice, equity, diversity and inclusion. We are committed to actively dismantling structural racism in our organization as described in more detail at: https://medschool.ucla.edu/diversity-anti-racism-roadmap.

To apply, please visit: https://recruit.apo.ucla.edu/JPF09392

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction

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About University of California Los Angeles

UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.

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